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Selected Publications:
2023
Chambers L.R., Ye Q., Cai J., Gong M., Ledvina H.E., Zhou H., Whiteley A.T., Suhandynata R.T., Corbett K.D. (2023) Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems. bioRxiv DOI: 10.1101/2023.09.26.559546. BIORXIV LINK
Enustun E., Armbruster E.G., Lee J., Zhang S., Yee B.A., Gu Y., Deep A., Naritomi J.T., Liang Q., Aigner S., Adler B.A., Cress B.F., Doudna J.A., Chaikeeratisak V., Cleveland D.W., Ghassemian M., Yeo E.W., Pogliano J.†, Corbett K.D.† (2023) A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. bioRxiv DOI: 10.1101/2023.09.22.559000 (†co-corresponding author). BIORXIV LINK
Gu Y., Li H., Deep A., Enustun E., Zhang D.†, Corbett K.D.† (2023) Bacterial Shedu immune nucleases share a common enzymatic core regulated by diverse sensor domains. bioRxiv DOI: 10.1101/2023.08.10.552793 (†co-corresponding author). BIORXIV LINK
Enustun E., Deep A., Gu Y., Nguyen K.T., Chaikeeratisak V., Armbruster E., Ghassemian M., Villa E., Pogliano J.†, Corbett K.D.† (2022) Identification of the bacteriophage nucleus protein interaction network. Nature Structural and Molecular Biology 30(11):1653-1662. (†co-corresponding author) PUBMED LINK | PDB 7UYX
Ledvina H.E.*, Ye Q.*, Gu Y., Quan Y., Lau R.K., Zhou H., Corbett K.D.†, Whiteley A.T.† (2023) An E1-E2 fusion protein primes antiviral immune signaling in bacteria. Nature 616(7956): 319-325 (*co-first author; †co-corresponding author) PUBMED LINK | PDBs 7TO3 7TQD 7TSQ 7TSX | EMDBs 26028 26066
Milano C.R.*, Ur S.N.*, Gu Y., Tromer E.C., Zhang J., Hochwagen A.†, Corbett K.D.† (2023) Chromatin binding by HORMAD proteins regulates meiotic recombination initiation. bioRxiv DOI: 10.1101/2023.03.04.531117 (*co-first author; †co-corresponding author) BIORXIV LINK | PDBs 7UBA 8CWW 8CZE | EMDBs 27030 27096
2022
Deep A.‡, Gu Y.‡, Gao Y.-Q., Ego K.M., Herzik M.A., Zhou H., Corbett K.D. (2022) The SMC-family Wadjet complex protects bacteria from plasmid transformation by recognition and cleavage of closed-circular DNA. Molecular Cell 82(21):4145-4159.e7. (‡co-first author) PUBMED LINK | PDBs 7TIL 8DK1 8DK2 8DK3 | EMDBs 25913 27480 27481 27482
Lau R.K., Enustun E., Gu Y., Nguyen J.V., Corbett K.D. (2022) A conserved signaling pathway activates bacterial immune signaling in response to DNA damage. The EMBO Journal 41(22): e111540. PUBMED LINK | PDBs 7T5T 7T5U 7T5V 7T5W
Laughlin T.G.‡, Deep A.‡, Prichard A.M., Seitz C., Gu Y., Enustun E., Suslov S., Khanna K., Birkholz E.A., Armbruster E., McCammon J.A., Amaro R.E., Pogliano J.†, Corbett K.D.†, Villa E.† (2022) Architecture and self-assembly of the jumbo bacteriophage nuclear shell. Nature 608(7922):429-435. (‡co-first author; †co-corresponding author) PUBMED LINK | PDBs 7SQQ 7SQR 7SQS 7SQT 7SQU 7SQV | EMDBs 25390 25391 25392 25394 25395 25396
Birkholz E.A., Laughlin T.G., Suslov S., Armbruster E., Lee J., Wittmann J., Corbett K.D., Villa E., Pogliano J. (2022) A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E. coli. Cell Reports 40(7):111179. PUBMED LINK
Liang Q.*, Richey S.T.*, Ur S.N., Ye Q., Lau R.K., Corbett K.D. (2022) Structure and activity of a bacterial defense-associated 3’-5’ exonuclease. Protein Science 31(7)e4374. (*co-first author) PUBMED LINK | PDB 7T2S
Corbett K.D., Herzik M.A. (2022) Electron counting takes microED to the next level. Nature Methods 19(6)652-653. PUBMED LINK
Blankenchip C.L., Nguyen J.V., Lau R.K., Ye Q., Gu Y., Corbett K.D. (2022) Control of bacterial anti-phage signaling by a WYL domain transcription factor. Nucleic Acids Research 50(9):5239-5250. PUBMED LINK | PDBs 7TB5 7TB6
Gu Y., Desai A., Corbett K.D. (2022) Evolutionary Dynamics and Molecular Mechanisms of HORMA Domain Protein Signaling. Annual Reviews of Biochemistry doi:10.1146/annurev-biochem-090920-103246. PUBMED LINK
2021
Ur S.N., Corbett K.D. (2021) Architecture and Dynamics of Meiotic Chromosomes. Annual Reviews of Genetics 55:497-526. PUBMED LINK
Ye Q., Lu S., Corbett K.D. (2021) Structural basis for SARS-CoV-2 nucleocapsid protein recognition by single-domain antibodies. Frontiers in Immunology 12:719037. PUBMED LINK | PDBs 7N0I 7N0R 7R98
Corbett K.D. (2021) A new phase in meiotic cell division. Nature 592(7852):32-33. PUBMED LINK
Lu S., Ye Q., Singh D., Cao Y., Diedrich J.K., Yates J.R., Villa E., Cleveland D.W., Corbett K.D. (2021) The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nature Communications 12(1): 502. PUBMED LINK
2020
Sato-Carlton A., Nakamura-Tabuchi C., Li X., Boog H., Lehmer M.K., Rosenberg S.C., Barroso C., Martinez-Perez E., Corbett K.D., Carlton P.M. (2020). Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans. PLoS Genetics 16(11):e1008968. PUBMED LINK
Corbett K.D. (2020). p31comet and TRIP13 recycle Rev7 to regulate DNA repair. PNAS 117(45): 27761-27763. PUBMED LINK
Clausen T.M., Sandoval D.R., Spliid C.B., Painter C.D., Pihl J., Thacker B.E., Glass C.A., Yang Z., Torres J., Golden G.J., Porell R., Feldman J., Yin X., Pu Y., Hauser B., Caradonna T., Kellman B.P., Martino C., Gordts P.L.S.M., Corbett K.D., Chanda Sumit K., Schmidt A.G., Godula K., Ward A., Carlin A.F., Esko J.D. (2020). SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2. Cell S0092-8674(20): 31230-31237. PUBMED LINK
Ye Q., West A.M.V., Silletti S., Corbett K.D. (2020) Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein. Protein Science 29(9): 1890-1901. PUBMED LINK | PDBs 6WZO 6WZQ
Ye Q., Lau R.K., Mathews I.T., Birkholz E.A., Watrous J.D., Azimi C.S., Pogliano J., Jain M., Corbett K.D. (2020) HORMA domain proteins and a Trip13-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity. Molecular Cell 77(4): 709-722. | PUBMED LINK | PDBs 6P80 6P82 6P8J 6P8O 6P8P 6P8R 6P8S 6P8U 6P8V 6PB3 6U7B
Lau R.K., Ye Q., Birkholz E.A., Berg K.R., Patel L., Mathews I.T., Watrous J.D., Ego K., Whiteley A.T., Lowey B., Mekalanos J.J., Kranzusch P.J., Jain M., Pogliano J., Corbett K.D. (2020) Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity. Molecular Cell 77(4): 723-733 | PUBMED LINK | PDBs 6P7O 6P7P 6P7Q 6Q1H 6UXF 6UXG
2019
Xu H., Tong Z., Ye Q., Sun T., Hong Z., Zhang L., Bortnick A., Cho S., Beuzer P., Axelrod J., Hu Q., Wang M., Evans S.M., Murre C., Lu L.F., Sun S., Corbett K.D., Cang H. (2019) Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy. Proc Natl Acad Sci USA 116(37):18423-18428. PUBMED LINK
Plowman R.*, Singh N.*, Tromer E.C., Payan A., Duro E., Spanos C., Rappsilber J., Snel B., Kops G.J.P.L., Corbett K.D.†, Marston A.† The molecular basis of monopolin recruitment to the kinetochore. Chromosoma 128(3):331-354 (*co-first author; †co-corresponding author) PUBMED LINK | PDBs 6MJ8 6MJB 6MJC 6MJE
Patel L.*, Kang R.*, Rosenberg S.C., Qiu Y., Raviram R., Chee S., Hu R., Ren B., Cole F.†, Corbett K.D.† (2019) Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. Nature Structural and Molecular Biology 26(3): 164-174 (*co-first author; †co-corresponding author) PUBMED LINK
West AMV*, Rosenberg SC*, Ur SN, Lehmer MK, Ye Q, Hagemann G. Caballero I, Uson I, Herzog F, Corbett KD. (2019) A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. eLife e40372 (*co-first author) PUBMED LINK | PDBs 6DD8 6DD9
Arora K, Corbett KD. (2018) The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding. Nucleic Acids Research 47(5):2365-2376. PUBMED LINK | PDBs 6BZF 6BZG
2018
Kim D.-H., Han J.S., Ly P., Ye Q., McMahon M.A., Corbett K.D.†, Cleveland D.W.† (2018) The mitotic checkpoint is silenced through a combination of TRIP3-mediated disassembly and APC15-driven ubiquitination/degradation of the mitotic checkpoint complex. Nature Communications 9:4354. PUBMED LINK
Singh N, Corbett KD (2018) The budding-yeast RWD protein Csm1 scaffolds diverse protein complexes through a conserved structural mechanism. Protein Science 27(12):2094-2100. PUBMED LINK | PDB 6DEI
Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR. (2018) Blocking Zika virus vertical transmission. Scientific Reports 8:1218. PUBMED LINK
Local A., Huang H., Albuquerque C.P., Singh N., Lee A. Y., Wang W., Wang C., Hsia J.E., Shiau, A.K., Ge K., Corbett K.D., Wang D., Zhou H., Ren B. (2018) Identification of H3K4me1-associated proteins at mammalian enhancers. Nature Genetics 50:73-82. PUBMED LINK | PDBs 5SZB 5SZC
West, A.M.V., Komives E.A., Corbett K.D. (2018) Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. Nucleic Acids Research 46:279-292. PUBMED LINK
2017
Corbett, K.D. (2017) Molecular mechanisms of spindle assembly checkpoint activation and silencing. Invited book chapter in Centromeres and Kinetochores, Springer book in series Progress in Molecular and Subcellular Biology 56:429-455. PUBMED LINK (request reprint)
Batra R., Nelles D.S., Pirie E., Blue S.M., Marina R.J., Wang H., Chaim I.A., Thomas J.D., Zhang N., Ngyuen V., Aigner S., Markiller S., Xia G., Corbett K.D., Swanson M.S., Yeo G.W. (2017) Microsatellite expansion RNA visualization, elimination, and reversal of molecular pathology by RNA-targeting Cas9. Cell 170(5):899-912. PUBMED LINK
Ye Q., Kim D.-H., Dereli I., Rosenberg S.C., Hagemann G., Herzog F., Tóth A., Cleveland D.W., Corbett K.D. (2017) The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. EMBO Journal 36(16):2419-2434. PUBMED LINK | JOURNAL LINK | PDBs 5VQ9 5VQA
Cheerambathur D.K., Prevo B., Hattersley N., Lewellyn L., Corbett K.D., Oegema K., Desai A. (2017) Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. Developmental Cell 41(4):424-437. PUBMED LINK
Liang J.*, Singh N.*, Carlson C.R., Albuquerque C.P., Corbett K.D.†, Zhou H.† (2017) Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes & Development 31: 802-815. (*co-first author; †co-corresponding author) PUBMED LINK | PDBs 5V1A 5V3N
2016
Ye Q., Ur S.N., Su T.Y., Corbett K.D. (2016) Structure of the S. cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. EMBO Journal 35(19):2139-2151. PUBMED LINK | PDBs 4XH0 4XHG 4XHH 4XHL 5CZO 5CZY
Meyer P., Socias S., Key J.,…Corbett K.D.,…Sliz P. (2016) Data publication with the structural biology data grid supports live analysis. Nature Communications 7:10882. PUBMED LINK | Structural Biology Data Grid
2015
Albuquerque C.P., Yeung E., Ma S., Fu T., Corbett K.D., Zhou H. (2015) A chemical and enzymatic approach to study site-specific sumoylation. PLoS One 10(12):e0143810. PUBMED LINK
Rosenberg, S.C., Corbett K.D. (2015) The multi-faceted roles of the HORMA domain in cellular signaling. The Journal of Cell Biology 211(4):745-755. PUBMED LINK
Nithianantham S., Le S., Seto E., Jia W., Leary J., Corbett K.D., Moore J.K., Al-Bassam J. (2015) Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics. eLife 4:10.7554/eLife.08811. PUBMED LINK
Ye Q., Rosenberg S.C., Moeller A., Speir J.A., Su T.Y., Corbett K.D. (2015) TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. eLife 2015;10.7554/eLife.07367. PUBMED LINK | PDB 4XGU
2014
Kim Y., Rosenberg S.C., Kugel C.L., Kostow N., Rog O., Dernburg A.F., Corbett K.D. (2014) The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. Developmental Cell 31(4):487-502. PUBMED LINK | PDBs 4TRK 4TZJ 4TZL 4TZM 4TZN 4TZO 4TZQ 4TZS
Sarangapani K.K., Duro E., Deng Y., de Lima Alves F., Ye Q., Opoku K.N., Ceto S., Rappsilber J., Corbett K.D., Biggins S., Marston A.L., Asbury C.L. (2014) Sister kinetochores are mechanically fused during meiosis I. Science 346(6206):248-51. PUBMED LINK.
2013
Bhandari D., Zhang J., Lord C., Menon S., Chen S., Corbett K.D., Ferro-Novick S. (2013) Sit4p/PP6 regulates ER to Golgi traffic by controlling the dephosphorylation of COPII coat subunits. Molecular Biology of the Cell 24(17): 2727-2738. PUBMED LINK
Xu D., Young J., Krahn J.M., Song D., Corbett K.D., Chazin W.J., Pedersen L.C., Esko J.D. (2013) Stable RAGE-Heparan Sulfate Complexes are Essential for Signal Transduction. ACS Chemical Biology. PUBMED LINK | PDB 4IM8
2012
Al-Bassam J., Corbett K.D. (2012) α-Tubulin acetylation from the inside out. Proceedings of the National Academy of Science USA 109(48):19515-19516. PUBMED LINK
Corbett K.D.*, Harrison S.C. (2012) Molecular Architecture of the Yeast Monopolin Complex. Cell Reports 1(6):583-589. PUBMED LINK | PDB 5KTB updated from original entry 4EMC
2011
Maddox P.S.*, Corbett K.D.*, Desai A. (2011) Structure, Assembly and Reading of Centromeric Chromatin. Current Opinion in Genetics & Development 22(2):139-147. PUBMED LINK
Cho U.-S., Corbett K.D., Al-Bassam J., Bellizzi J.J., De Wulf P., Espelin C.W., Miranda J.J., Simons K., Wei R.R., Sorger P.K., Harrison S.C. (2011) Molecular Structures and Interactions in the Yeast Kinetochore. Cold Spring Harbor Symposia on Quantitative Biology 75:395-401. PUBMED LINK
2010
Corbett K.D., Yip C.K., Ee L., Walz T., Amon A., Harrison S.C. (2010) The monopolin complex cross-links kinetochore components to regulate chromosome-microtubule attachments. Cell 142(4): 556-567. PUBMED LINK | PDBs 3N4R 3N4S 3N4X 3N7N